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SGLT2 inhibitors during pregnancy Animal None of the SGLT2 inhibitors showed developmental toxicity when a dose not resulting in maternal toxicity was administered during the interval coinciding with the first trimester period of organogenesis except for canagliflozin, where ossification delays of the metatarsal bones were seen ( Table 2 )

doi:10.2337/db12-0202 241

Hay M, Thomas DW, Craighead JL, et al

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