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Because the side effect profile of SGLT2is differs from that of GLP-1RAs, any additive negative interaction is not expected when these two classes of anti-diabetic medications are used in combination [11]

2013 Nov;37(11):1514

Saxenda 3 mg daily for weight management): Proven efficacy with 5-8% weight reduction and cardiovascular outcome benefits in the LEADER trial Dulaglutide (Trulicity 0.75-4.5 mg weekly): Convenient once-weekly dosing with demonstrated cardiovascular benefit in the REWIND trial Tirzepatide (Mounjaro for diabetes

The combination is designed to produce additive weight loss beyond what either molecule achieves independently

The trio has far fewer resources and less manufacturing capacity than Amgen or Pfizer, but that could change if they get scooped up by a large drugmaker

The authors point out that other classes of drugs, including those treating erectile dysfunction and an anti-arrythmic drug, have previously been found to cause NAION in some patients