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Tirzepatide (Mounjaro, Zepbound) is a dual GIP/GLP-1 receptor agonist, not a GLP-1 receptor agonist

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[4] [5] Imbalanced GLP-1 function may manifest as either insufficient production or impaired receptor sensitivity, though there is no official clinical definition of "GLP-1 imbalance" as a distinct diagnostic entity

The active forms of endogenous GLP-1 are primarily GLP-1(7-36) amide and, to a lesser extent, GLP-1(7-37)