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National Institute of Clinical Excellence

The combination raises dehydration risk fast you can lose fluids from both ends in a matter of hours

Because of its potency, scientific backing, and tolerability, Retatrutide has become one of the most in-demand weight management peptides available in Canada

Many patients experience reduced appetite and fluid intake when starting GLP-1 therapy, whilst the medicine's gastrointestinal effects including nausea and occasional vomiting can further affect hydration status

Healthy fats may support GLP-1 response, though evidence is mixed and context-dependent

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