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While GLP-1 lowers blood glucose levels by promoting insulinotropic actions [70], glucagon promotes hyperglycaemia by stimulating hepatic glucose production [56]

This creates an interesting divergence

In the STEP 1 and STEP 3 trials, participants with a mean BMI of 38 showed around 15% weight loss after 68 weeks treatment with 2.4mg semaglutide

Always consult a healthcare professional

Community endocrinologists and primary care physicians also favor prescribing to hospital pharmacies in some cases due to the latter's direct engagement with diabetes educators, nutritionists and other specialists

Only one study did not identify any benefit of GLP-1RAs in animal models of opiate misuse, although this same study had shown a positive effect for alcohol misuse 63