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The same mechanism that suppresses appetite, delayed gastric emptying and reduced food intake signaling, also causes the nausea, fullness, and digestive changes that patients report most frequently

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Transitioning to non-insulin therapy in a patient receiving high dose insulin

If prescribed, patients should follow a low-fat diet and take any fat-soluble vitamin supplements at least 2 hours before or after orlistat

Such effects could plausibly involve relaxation of blood vessels, improved renal salt handling and reduced stress signalling, all of which may contribute to lower blood pressure

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