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Patients taking naltrexone regularly report that drinking feels less pleasurable

Importantly, GLP-1 injection into the ARC was shown to decrease the activity of agouti-related peptide (AgRP) neurons and their strong orexigenic effect and to activate the pro-opiomelanincortin (POMC) neurons, which are prominent in satiety via melanocortin pathways [50,55,56]

However, as an early-generation GLP-1 drug it requires daily dosing, whereas semaglutide can be taken weekly

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[DOI] [PubMed] [Google Scholar] 16.Heerspink HJ, Parving HH, Andress DL, Bakris G, CorreaRotter R, Hou FF, et al

Zhao, X., Wang, M., Wen, Z., Lu, Z., Cui, L., Fu, C., Xue, H., Liu, Y., & Zhang, Y