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Adherence to lifestyle modifications is another critical factor

Additionally, monocyte and macrophage marker cluster of differentiation 68 (Cd68) and monocyte chemoattractant protein-1 (Mcp-1) levels were lowered when treated with GIPR/GLP1R agonists

Retatrutide, a triple hormone receptor agonist for obesity: A randomized, phase 2 trial

Finally, since endogenous GLP-1 is involved in the regulation of energy metabolism both in the periphery as well as in the brain, compounds acting as GLP-1R agonists can also normalize mitochondrial function, which also appears to be repeatedly disrupted in the depressive brain and thus possibly exacerbate neuroprotective effects, e.g

Semaglutide is often less expensive than tirzepatide, which may be a deciding factor

How we reviewed this article: Samantha Snashall, RDN, LD