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Transition 1: Principal component 1

Because pancreatin degradation assays are relevant to predict the stability of peptides in the gastrointestinal tract 52 , our data thus suggest that hybrid 24 could be suitable for oral administration and the peptide/oligourea hybrid approach reported here would be used to improve pharmacokinetic properties of some peptide-based drugs

HR, 1.10 [95% CI, 0.92-1.32]

"This suggests that for many patients, these medications aren't being abandoned permanently

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[DOI] [PMC free article] [PubMed] [Google Scholar] [119].Blevins T, Pullman J, Malloy J, Yan P, Taylor K, Schulteis C, Trautmann M, Porter L, DURATION-5: exenatide once weekly resulted in greater improvements in glycemic control compared with exenatide twice daily in patients with type 2 diabetes, The Journal of clinical endocrinology and metabolism, 96 (2011) 13011310