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The most advanced of them, danuglipron, has demonstrated good efficacy in a twice-daily formulation, and we believe a once-daily formulation has the potential to have a competitive profile in the oral GLP-1 space," said Mikael Dolsten, MD., PhD., chief scientific officer & president, Pfizer Research and Development

Given its potency, this technically means that Retatrutide, once approved by the FDA, may be suitable for both type 2 diabetes and obesity and provide new approaches to bariatric surgery

[1] [2] Whilst these mechanisms contribute to improved glycaemic control and weight reduction, they also account for one of the most commonly reported adverse effects: nausea

In rectosigmoid biopsies from patients with constipation-predominant IBS and healthy controls, GLP-1R was significantly downregulated in IBS individuals compared to controls [55]

You should seek medical advice if you experience significant changes, such as missed periods, unusually heavy or light bleeding, persistent or worsening cramps, or unexpected spotting - especially if you're on HRT or havent had periods for some time

You've tried diet and exercise alone without lasting results