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Safety, Tolerability, and Who Should Consider This Dose A 40-unit maintenance dose is generally well-tolerated in individuals without contraindications, though gastrointestinal side effects (nausea, constipation, diarrhea) remain common, particularly during escalation

Similarly, semaglutide ameliorates doxorubicin-induced cardiotoxicity by reducing BNIP3-mediated mitochondrial dysfunction through the PI3K/AKT pathway, enhancing mitochondrial function and reducing cardiac injury (Li et al., 2024), potentiating its clinical application in cardiovascular diseases

In some cases, if a patient is prescribed a GLP-1 for diabetes or obesity and experiences an improvement in their OSA, this could be considered a positive outcome, even if the drug wasnt specifically prescribed for the sleep disorder

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Serious but rare side effects require immediate medical attention

I was deeply skeptical of GLP-1 medications