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Although there were no differences in magnitude between conditions (P>0.11), the postprandial GLP-1 peak response to breakfast intake was delayed by 90min following sleep loss in comparison with regular sleep (P<0.02)
It is meant to be used in conjunction with a reduced-calorie diet and increased physical activity
The STEP 1 trial showed up to 45% of weight lost on semaglutide was lean mass
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