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Leptin and gene therapy Leptin has been recognized as one of the therapeutic candidates for obesity and as a regulator of fat mass, but its therapeutic effect is limited because of the apparent development of leptin resistance and the decreased BBB transport that is, observed in obese subjects with elevated blood leptin levels

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Some patients may also need weight-loss medication, and some may require additional surgeries

Management of hyperglycaemia in type 2 diabetes: a patient-centered approach

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Pinto SFT, Santos HA, Sarmento B