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Long-term management strategies are therefore required that are effective at controlling dysglycaemia, well tolerated and, ideally, offer additional cardiovascular disease (CVD) risk-reduction benefits

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Understanding the mechanism, recognizing individual variation, and working with a provider to optimize dosing can help manage this side effect

It is commonly incorporated into triple-pathway experimental models focused on nutrient sensing, incretin pathway activity, metabolic signaling efficiency, and coordinated energy-balance research under sustained nutrient exposure conditions