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Nutritional patterns like the low carbohydrate diet and ketogenic diet can target reduction of de novo lipogenesis and increase fatty acid oxidation that will eventually help insulin resistance downstream [62,67,70,88,89]

We thank Daniel Drucker and Anthony Gramolini (Toronto, Canada) and Gary Lopaschuk (Edmonton, Canada) for helpful discussions and Daniel Drucker for providing the Glp1r / mice

(2023, July 20)

Nrregaard PK, Deryabina MA, Shelton PT et al (2018) A novel GIP analogue, ZP4165, enhances glucagon-like peptide-1-induced body weight loss and improves glycaemic control in rodents

Note: This study is about Zepbound (tirzepatide), not Foundayo (orforglipron)