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Tirzepatide is administered as a once-weekly subcutaneous injection , typically starting at a low dose (2.5 mg) and gradually titrated upwards (to 5 mg, 7.5 mg, 10 mg, 12.5 mg, or 15 mg) at approximately 4-week intervals to optimise efficacy whilst minimising gastrointestinal side effects

doi: 10.1001/jama.288.20.2579

The Observer recently reported on a lack of transparency around the companys efforts to promote semaglutide for obesity

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For two of the KQs, there was insufficient direct, comparative data to make an evidence-based recommendation