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4.2 Body weight loss Patients with T2DM treated with certain GLP-1RAs have reported experiencing weight loss (Vilsbll et al., 2012)

The STEP 4 trial found that stopping semaglutide led to partial weight return even when lifestyle changes persisted, indicating medication plays a structural metabolic role

So I think that fits very well with effects on the reward system

I've tried everything over the past decade this is the first time something actually worked and I didn't feel like I was fighting my body the whole time." Amanda K

Slower Gastric Emptying: The medication slows down the rate at which food leaves the stomach, contributing to a prolonged feeling of fullness

Crumm, S., Cofan, M., Juskeviciute, E