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An association between dipeptidyl peptidase-4 (DPP-4) inhibitor treatment and heart failure has been observed in cardiovascular outcomes trials for two other members of the DPP-4 inhibitor class

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GLP-1s are generally prescribed for adults with type 2 diabetes who have not been able to achieve adequate blood sugar control with oral medications such as metformin

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FIGURE 1 3.3 Signal values associated with different GLP-1 RAs We identified signals of AP events associated with all GLP-1 RAs using the criteria established by the four algorithms, and the results are summarized in Table 3

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