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Exendin-4, a glucagon-like peptide 1 receptor agonist, protects against amyloid-beta peptide-induced impairment of spatial learning and memory in rats

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Clinical data shows semaglutide (Wegovy) produces 1022% weight loss over 68 weeks and sustains results long-term, while phentermine typically yields 57% weight loss over 12 weeks with rebound after discontinuation

doi: 10.1016/j.jacc.2020.05.037 38 DaviesMJDAlessioDAFradkinJKernanWNMathieuCMingroneGet al

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The most frequently reported adverse effects of GLP-1 receptor agonists are gastrointestinal in nature, including nausea, vomiting, diarrhea, constipation, and abdominal discomfort
