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Genetic and metabolic factors contribute to individual variability

Overall agreement 90%: A+ 70%, A 20%, A 0%, D 10%, D 0%, D+ 0%

Higher-risk patients include those in the dose-escalation phase, those with nausea, vomiting, bloating, abdominal pain, early satiety, or reflux symptoms, those on higher doses with GI side effects, and those with known gastroparesis or other conditions that slow gastric emptying

Obesity and cancer mechanisms: Tumor microenvironment and inflammation

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GPR-120 is expressed by chondrocytes in culture [46], and its role in OA was investigated by inducing the ACLT post-traumatic OA model in GPR-120knockout mice