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The information is publicly visible: Because anyone can access FAERS, media coverage, or social media chatter can amplify a perceived link, which in turn may drive more selfreports, reinforcing the appearance of an association

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Pioglitazone also attenuated endothelin-1induced vasoconstriction by downregulating cyclooxygenase-2 (COX-2) via activator protein-1 (AP-1) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-B), while enhancing NO bioavailability [148]

However, some doctors may prescribe it off - label for women with PCOS, particularly when insulin resistance or weight gain are major concerns

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