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118 European Medicines Agency (2022) ULTOMIRIS (ravulizumab) Summary of opinion Howard JF, Bresch S, Genge A et al (2023) Safety and efficacy of zilucoplan in patients with generalised myasthenia gravis (RAISE): a randomised, double-blind, placebo-controlled, phase 3 study

15 This divergence between small molecule (5 years) and biologic (12 years) exclusivity has created a strategic incentive for pharmaceutical companies to prioritize biological development, particularly in light of new pricing negotiation frameworks that treat the two modalities differently

Patients should be counselled that weight loss with semaglutide is gradual, with maximum effects typically seen after 6068 weeks of treatment, as demonstrated in the STEP clinical trial programme

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The DURATION-1 and DURATION-5 clinical trials, which directly compared exenatide BID (Byetta) to exenatide QW (Bydureon), reported better HbA1c level reduction for Bydureon [119, 120]

Similarly, the relative effects of treatments compared to placebo were assigned normal priors with a mean of zero and the same precision