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NICE has recommended Wegovy (semaglutide) for reducing the risk of major adverse cardiovascular events in patients with existing cardiovascular disease who are overweight or obese

Finally, Aspiration considers these companies value propositions, available patents, real-world impact and clinical studies of their solutions, and total market potential, while concurrently considering their ongoing commitment to leveraging AI and ML algorithms

Key Takeaways Retatrutide is a first-in-class triple agonist targeting GLP-1, GIP, and glucagon receptors developed by Eli Lilly Phase 2 results: Up to 24.2% body weight loss at the highest dose (12 mg) over 48 weeks, published in the New England Journal of Medicine Phase 3 TRIUMPH trials: Ongoing across 5 indications including obesity, type 2 diabetes, and MASH (fatty liver disease)

These medicines exert direct and indirect effects on the brain, improving neuronal health and thereby impacting a range of central nervous system disorders, including stroke, substance use disorders, Parkinsons disease, and Alzheimers disease

Imaging data capture and analysis OB and LH sections processed for cFos in situ hybridisation were imaged with a Slide Scanner (Nanozoomer 2.0 HT, Hamamatsu, Japan)

Baseline metabolic status significantly affects response time