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[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Bailey CJ, Flatt PR, Conlon JM

In hyperglycaemia, GOx co-encapsulated with a GLP-1 analogue oxidizes excess glucose to gluconic acid, lowering the local pH and triggering dissolution of acid-labile mineral or polymer matrices

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Its typically most noticeable during dose increases and usually improves within 1-2 weeks

10.1016/S0140-6736(16)31009-1 [EL 1