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2024;384:e075847

Volz A, Gke R, Lankat-Buttgereit B, Fehmann HC, Bode HP, Gke B

Its Phase 2 obesity trial published in Lancet Diabetes & Endocrinology (2024) showed up to 18.7% weight loss at 46 weeks, while a separate Phase 2 MASH trial demonstrated significant MASH resolution, earning FDA Breakthrough Therapy Designation

A surgeons ability to offer both surgical and non-surgical options is an important differentiator in 2026
GLP-1s are indeed a powerful new tool for combating unhealthy weight gain and are effective at suppressing the desires that drive unhealthy behaviors like overeating

However, human resource decision-makers in charge of employee health plans acknowledge GLP-1s as beneficial for controlling blood sugar, boosting weight loss, and improving blood pressure, but 38% percent cited cost as a potential barrier to providing coverage
