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First, as a retrospective observational analysis using EHR data, residual confounding is possible, even though we employed PSM and adjusted for known psychiatric and metabolic covariates, as well as socioeconomic status and lifestyle-related factors (smoking and alcohol use)

Following drug intervention, all three treated groups showed significant improvements in these parameters compared to untreated db/db mice [1]

These injectable drugs, when used alongside a healthy diet and regular exercise, can help patients achieve an average weight loss of 15%

This means the pharmacological gap between doses is narrower

However, individual responses to Saxenda vary considerably , and some patients report persistent or even increased hunger despite adherence to the prescribed dose escalation schedule