semaglutide and als Full article: Targeting metabolic dysfunction in amyotrophic lateral sclerosis: therapeutic potential of GLP-1 receptor agonists Update on diagnostics and therapy

Hi everyone As we are all aware, GLP-1based therapies are transforming the obesity and metabolic disease landscape, with the market projected to cross $100B+ in the coming decade

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GLP-1 receptors are distributed throughout the central nervous system, including in the hypothalamus and the mesolimbic reward system the very dopamine-rich pathways involved in craving, motivation and emotional eating

Lillys oral GLP-1 candidate,orforglipron, delivered a12.4% average body weight reductionin a Phase 3 trial over 72 weeks

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