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This effect may be attributed to the appetite-suppressing and weight-reducing effects of GLP-1 RAs, which decrease postprandial lipoprotein secretion and mitigate systemic inflammation

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Additional comparative evidence comes from: A 2025 narrative review synthesising randomised and indirect comparison data across obesity and type 2 diabetes trials, confirming tirzepatides superiority on weight and HbA1c [2]

What could delay approval is if the remaining TRIUMPH trials show higher rates of dysesthesia, more severe cases, or unexpected long-term consequences
