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Protease-Independent Metabolic Effects of DPP-4 While some of the effects of DPP-4and, arguably, most, if not all of the pharmacological effects of DPP-4 inhibitors (38)on glucose homeostasis are mediated primarily by modulating the activity of the incretin hormones, it has also been proposed that DPP-4 may influence metabolic control via mechanisms which do not necessarily involve its catalytic activity, with several studies noting a positive correlation between DPP-4 and insulin resistance (79, 81, 88)

Wells, J

Spicy foods, acidic items like citrus fruits or tomatoes, and carbonated beverages can also irritate the digestive system during this sensitive period