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Receptors of these incretins, GLP-1R and GIPR are G protein-coupled receptors (GPCR) that activate the classical signaling cascade through Gs and adenylate cyclase (Adcy), leading to increased cAMP production [6,7]

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GLP-1 is a naturally occurring hormone in your body that is released in your gut after you eat

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Globally, there are nearly 46.8 million people suffering from AD, and treatment costs were estimated at USD 818 billion in 2015

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doi: 10.1016/j.cell.2019.03.044 110 LiuZHrubyVJ

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