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This umbrella review synthesizes the evidence for safety and efficacy GLP-1 receptor agonists on multiple outcomes including but not limited to metabolic, cardiovascular and renal outcomes.

Case reports document perioperative aspiration in semaglutide users, including episodes of hypoxemia and reintubation despite guideline-concordant fasting

Conclusion GLP-1 RA therapy has a respiratory safety profile that is neither uniformly benign nor hazardous, stratified by mechanism, agent subclass, and clinical context

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Gastrointestinal (GI) adverse eventsparticularly nausea, vomiting, diarrhea, and constipationare the most common side effects, generally emerging during dose escalation and resolving over time