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Unfortunately, GLP-1 is rapidly degraded by the enzyme dipeptidyl peptidase-4 (DPP-4), which limits the therapeutic efficacy of native GLP-1 (Deacon et al., 1995)

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Source: Cell Press Some people taking GLP-1 drugs for diabetes and obesity experience mental health benefitsparticularly, a decrease in symptoms of depression

However, while the processes of exocytosis are similar to those in neuronal cells, the kinetics of release are quite different