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The current evidence does not support a definitive causal link between these medications and suicidal ideation, though ongoing pharmacovigilance continues to monitor for potential signals

According to WebMD, clinical trials measured results at maintenance doses, with participants losing an average of 15% of body weight over 68 weeks

The cAMP/PKA pathway, in concert with the PI3K/protein kinase C (PKC) pathway (discussed in more detail below), also inhibits voltage-gated potassium channels, which in response to depolarization, opens and allows K + efflux, repolarizing the cell (MacDonald et al., 2003)