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Sin embargo, presentan algunas limitaciones: Nuseas y molestias digestivas Necesidad de prescripcin mdica Coste elevado Efecto rebote tras la retirada Este ltimo punto es clave: al suspender el tratamiento, el apetito vuelve y puede recuperarse el peso perdido

This examination may be subject to debate in the face of extremely low central ghrelin levels

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Furthermore, GLP-1 agonists preserve mitochondrial integrity, reduce endoplasmic reticulum stress, and inhibit cardiomyocyte apoptosis through activation of the PI3K/Akt and AMPK pathways [82]