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In patients on insulin or sulphonylureas, the same process can cause a significant and dangerous blood glucose drop

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The field is moving fast, perhaps faster than the safety data can accumulate

The finding that exogenous stimulation of GLP-1R results in suppression of food intake irrespective of its macronutrient content is perhaps consistent with previous data that indicate that all macronutrients (carbohydrates, fat, proteins) can induce the release of GLP-1 from the intestinal L-cells (Reimann, 2010

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These lipids contribute to cardiovascular disease by promoting inflammation, oxidative stress, endothelial dysfunction, and the transport of LDL into blood vessel wall cells, contributing to atherosclerosis and a host of cardiometabolic problems such as hypertension, obesity, and type 2 diabetes