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Medications in this approach include modulation of peroxisome proliferator-activator receptors (e.g., pemafibrate, elafibranor), medications targeting farnesoid X receptor axis [obeticholic acid

The Safety, Tolerability and Efficacy of Rapid UpTitration of GuidelineDirected Medical Therapies in Acute Heart Failure (STRONG-HF) trial validated rapid up-titration strategies, demonstrating that early high-intensity GDMT implementation with structured follow-up significantly reduces 180-day mortality and readmissions
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