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Therefore, our current study is consistent with a model where, during HFHC dietinduced metabolic dysregulation, the deletion of Dpp4 within Tie2 + cells increases the abundance of GLP-1 delivered to the systemic circulation, enabling the incretin effect, and improves oral glucose tolerance but does not affect HGP

GLP-1 exerts several key physiologic effects: Increases glucose-dependent insulin secretion Suppresses inappropriate glucagon release Delays gastric emptying Promotes satiety and reduces appetite Pharmacologic GLP-1 receptor agonists, including semaglutide, liraglutide, and tirzepatide, are engineered to resist DPP-4 degradation, allowing them to persist for hours to days

Fatigue, headaches, dizziness, and muscle cramps are often hydration and electrolyte issues in disguise
In a third trial, liraglutide significantly reduced weight by 8 pounds relative to placebo over 10 months in stable patients with bipolar disorder regardless of whether they were taking an antipsychotic (McElroy SL et al, J Clin Psychopharm 2024;44(2):8995)

Journal Reference : Hamlet Gasoyan, Mohammad Hesam Alavi, Alexander Zajichek, Nicholas J
