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Cholinergic hypothesis states that the degeneration of basal forebrain neurons in AD patients leads to dysfunction and death of cholinergic neurons in the forebrain, followed by extensive presynaptic denervation occurs, and the loss of specific subtypes of acetylcholine receptors, leading to cognitive decline in AD patients (39)

They work because sweet cravings on GLP-1 don't disappear the way hunger does

Yazici D, Yapici Eser H, Kiyici S, Sancak S, Sezer H, Uygur M, et al

GLP-1 receptor agonists were initially developed to improve glycemic control in type 2 diabetes by enhancing insulin secretion and inhibiting glucagon release, with additional effects on appetite regulation and gastric emptying later recognized as clinically relevant (Chao et al

The GLP-1 elevations observed with allulose consumption are generally small and transient compared to those achieved with pharmaceutical GLP-1 receptor agonists such as semaglutide or liraglutide, which produce sustained and pharmacologically significant increases in GLP-1 activity
