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Peptide-encoding mRNA barcodes for the high-throughput in vivo screening of libraries of lipid nanoparticles for mRNA delivery
Hatcher calls it the "worst medication I've ever taken," but it's "infinitely cheaper" than GLP-1s and similarly addresses insulin resistance, Pea says
110 Similar to beta-cells, alpha-cells rely on ATP-dependent K + (KATP) channels to play a key role in promoting exocytosis of intracellular granules, as they couple flux of glucose concentration in circulation to changes in membrane potential and calcium influx
By the 1960s, researchers had demonstrated the incretin effect the phenomenon where glucose taken orally triggers much higher insulin release than glucose given intravenously
10.1016/j.molmet.2019.09.010 131
