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Gastrointestinal Tolerability Over Time GI symptomsespecially nausea, vomiting, and constipationare among the most common complaints in GLP1 therapy

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GLP-1 receptor agonists and DPP4-inhibitor direct the T2DM therapies

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Notably, the only property all these poly-ligands share is that they all activate the GLP-1R, albeit with varying potencies (Figure 3)

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