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Promising therapeutic avenues are being explored that may transform the PD therapeutic landscape in the coming years, including stem cell transplantation, gene therapies that deliver circuit-modifying and neuroprotective factors to specific brain targets via viral vectors, and potential disease-altering oral agents

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doi: 10.3389/fonc.2024.1392375 Received 27 February 2024 Accepted 02 April 2024 Published 18 April 2024 Volume 14 - 2024 Edited by Karuna Rasineni, University of Nebraska Medical Center, United States Reviewed by Luigi Losco, University of Salerno, Italy Asher Rajkumar Rajan, University of Nebraska Medical Center, United States Updates Copyright 2024 Crowley, Brown, Gallagher and Dayan

This occurs because cortisol preferentially stimulates adipocyte differentiation and lipid accumulation in visceral depots while promoting protein catabolism in skeletal muscle