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The most common adverse reactions reported in patients treated with semaglutide include nausea, vomiting, diarrhea, abdominal pain, and constipation.[5-7] Semaglutide may also increase the risk of pancreatitis, acute gallbladder disease, hypersensitivity reactions, acute kidney injury, and thyroid C-cell tumors.[5-7] Whether semaglutide is safe in people with pancreatitis remains unclear.[5-7] It is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN 2).[5-7] How Long Will Semaglutide Weight Loss Results Last

MMP-8, also known as collagenase-2, is a specific collagenase released by polymorphonuclear neutrophils (PMNs) that preferentially cleaves fibrillar collagens, notably types I and III [91]

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Not a description of effects in humans

However, comparing the two directly, some research suggests that Semaglutide GLP-1 may offer a slight edge in overall weight reduction percentages

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