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Caloric restriction alone often fails because insulin dysfunction prevents efficient fat mobilization

It slows gastric emptying, signals fullness to the brain, and boosts insulin release while suppressing glucagon, stabilizing blood glucose

Importantly, the levels of these neurotransmitters can be different according to the phase of BD (Fig

The dehydration connection This is the biggest indirect risk factor

Studies were pulled from Embase, Web of Science, Scopus, Medline, PubMed, the Cochrane Library, PsycINFO, and Google Scholar

If you regain more than 2 to 3 pounds, consider staying at 10 mg for an additional 2 to 4 weeks before moving to the next step