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subscription) Whether you use insurance or pay direct How dosage and duration of treatment impact affordability Treatment with GLP-1 receptor agonists typically begins at a low dose and increases gradually over several weeks until reaching a maintenance dose (usually 3.0 mg daily) to optimize weight loss

Uniquely, these two agents from the same company may work as a complementary pair: the ATTAIN-MAINTAIN trial demonstrated that patients can achieve maximum weight loss with injectable tirzepatide and then switch to oral orforglipron for maintenance