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Tuttle, Mechanisms and clinical applications of incretin therapies for diabetes and chronic kidney disease

Methodology: The study authors conducted an exhaustive search through Medline and the Cochrane Library for RCTs assessing the maintenance doses of subcutaneous tirzepatide at 5, 10, or 15 mg once-weekly, or subcutaneous semaglutide at 0.5, 1.0, or 2.0 mg once-weekly, spanning a minimum of 12 weeks

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This suggests that common GIPR variants can modulate GIP-mediated glucose metabolism, potentially affecting tirzepatide response