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What is the connection between obesity and ADHD? Adults with ADHD develop obesity at rates 23 times higher than neurotypical controls, driven by shared genetic variants affecting dopamine signaling and reward processing

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13 February 2026 A Correction to this paper has been published: Abbreviations ALT: Alanine transaminase ANOVA: Analysis of variance ARRIVE: Animal Research: Reporting of In Vivo Experiments AST: Aspartate aminotransferase BM: Body Mass DNA: Deoxyribonucleic acid DIO: Diet-induced obesity DXR: Doxorubicin ECL: Electrochemiluminescence FFPE: Formalin fixed paraffin embedded HBSS: Hanks balanced salt solution H&E: Haematoxylin & eosin HFD: High fat diet IVC: Individually ventilated cages IL-6: Interleukin-6 JNK: Jun N-terminal kinase MCP-1: Monocyte chemoattractant protein-1 NAFLD: Non-alcoholic fatty liver disease NAS: Non-alcoholic fatty liver disease activity score NF-kB: Nuclear factor kappa-light-chain-enhancer of activated B cells NT: Non-Tumour PVDF: Polyvinylidene difluoride RES: Reticuloendothelial system RIP1: Receptor-interacting protein 1 RIPA: Radio-immunoprecipitation assay buffer ROS: Reactive oxygen species RT: Room Temperature SD: Standard diet SDS: Sodium dodecyl sulfate TBS-T: Tris-buffered saline tween T2DM: Type 2 Diabetes Mellitus T: Tumour Top 2: Topoisomerase II V: Vechile References Francies FZ, Hull R, Khanyile R, Dlamini Z

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