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GLP-1 agents demonstrate 15-22% reduction over 68 weeks in trials (tirzepatide) and 10-15% over similar periods (semaglutide)

Also, preclinical studies have shown that the dual combination of GIP and glucagon (GCG) agonists has a more pronounced reduction in hepatic triglycerides and improvement in liver histological disease activity scores than GLP-1RA (liraglutide)

Media reports describe women with stomach paralysis, with severe effects continuing at least a year after discontinuing in two of three cases