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[DOI] [PMC free article] [PubMed] [Google Scholar] 84.Wang T, Wang F, Gou Z, Tang H, Li C, Shi L, Zhai S

The CDC considers obesity a chronic disease that increases the risk of heart disease, Type 2 diabetes, stroke, certain cancers, liver disease, and other serious health conditions

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Also, small molecule PAMs of GLP-1 have been found that can potentiate the action of GLP-1 (7-36) and its metabolite GLP-1 (9-36), which retains some weak activity (EC 50 = 1.8 M, E MAX = 13%) for GLP-1R