can you get off glp 1 GLP-1 drugs without gaining weight Most Patients Keep Weight Off
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This leads to a reduced appetite and, when combined with a healthy diet and regular exercise, can result in significant weight loss over time
Diabetologia 49 , 20492057 (2006)
The Numbers That Matter: In the landmark SURMOUNT-5 trial published in the New England Journal of Medicine in May 2025, participants taking tirzepatide lost an average of 20.2% of their body weight over 72 weeks, compared to 13.7% with semaglutide
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However, if you are also taking sulfonylureas or insulin, adding even a microdose of tirzepatide could push blood glucose too low
In the future, new drugs targeting insulin-related signal pathways may pave a novel way for suppressing PDA initiation and progression
