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Additionally, these molecules often exist as higher-order aggregates (e.g., multimers), rather than simple monomers, necessitating advanced characterisation

However, in clinical practice higher doses up to 2.0 mg are used in patients with T2D, and up to 2.4 mg/week in patients with obesity without T2D

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This creates an ecological vacuum in the microbiome, allowing opportunistic pathogens and pro-inflammatory Gram-negative bacteria, such as Streptococcus and certain Clostridium species, to proliferate unchecked

Clinical studies show obese PCOS patients lose an average of 7.6-11.5 kg over 6 months, with up to 80% achieving menstrual cycle normalization